Working in Medical Genomics group with Mark Ross and David Bentley

Principal research:

• Integrating RNA-seq expression data with clinical cancer genome analysis
• Benchmarking sensitivity of variant detection for targeted cancer panels and comparing their performance to cWGS
• Developing a method for estimation of tumour content in a sample from transcriptome data

• Supervised by Boris Lenhard
• PhD student aiming to understand spatio-temporal gene expression during zebrafish embryogenesis
• Thorough reanalysis of of all publicly available mRNAin situhybridisation data from zebrafish development led us to develop Anatom-ical specificity coefficient that tells about relative size of anatomical structures
• Elucidated the role of core promoters in regulation and gene function that is a foundation to PromoterOntology methodology
• Integrating numerous NGS datasets (RNA-seq, CAGE, ChIP-seq, ATAC-seq and scRNA-seq) with goal to understand how multiple layersof gene regulation communicate together to create final gene expression profiles. This process is crucial for early embryonic devel-opment.

• Supervised by Frances Williams and Tim Spector
• Developed linear mixed effect models for twin data design in analysis of complex disease - lower back pain.
• Identified new glycomic biomarkers of back pain that could be used for early detection of disease